| DAT | MOTSTÅNDARE | RESULTAT | MÅLGÖRARE | pl | |
| 14 aug | b | Wigan | 1-0 |
Crespo | |
| 21 | H | ARSENAL | 1-0 | Drogba | |
| 24 | H | WEST BROMWICH | 4-0 | Lampard 2, Cole, Drogba | |
| 27 | b | Tottenham | 2-0 | Del Horno, Duff | |
| 10 sep | H | SUNDERLAND | 2-0 | Geremi, Drogba | |
| 17 | b | Charlton | 2-0 | Crespo, Robben | |
| 24 | H | ASTON VILLA | 2-1 | Lampard 2 (1 str) | |
| 2 okt | b | Liverpool | 4-1 | Lampard str, Duff, Cole, Geremi | |
| 15 | H | BOLTON | 5-1 | Drogba 2, Lampard 2, Gudjohnsen | |
| 23 | b | Everton | 1-1 |
Lampard | |
| 29 | H | BLACKBURN | 4-2 | Drogba, Lampard 2 (1 str), självmål | |
| 6 nov | b | Manchester United | 0-1 |
||
| 19 | H | NEWCASTLE | 3-0 | Cole, Crespo, Duff | |
| 26 | b | Portsmouth | 2-0 | Crespo, Lampard str | |
| 3 dec | H | MIDDLESBROUGH | 1-0 | Terry | |
| 10 | H | WIGAN | 1-0 | Terry | |
| 18 | b | Arsenal | 2-0 | Robben, Cole | |
| 26 | H | FULHAM | 3-2 | Gallas, Lampard, Crespo | |
| 28 | b | Manchester City | 1-0 | Cole | |
| 31 | H | BIRMINGHAM | 2-0 | Crespo, Robben | |
| 2006 2 jan |
b | West Ham | 3-1 | Lampard, Crespo, Drogba | |
| 14 | b | Sunderland | 2-1 | Crespo, Robben | |
| 22 | H | CHARLTON | 1-1 |
Gudjohnsen | |
| 1 feb | b | Aston Villa | 1-1 |
Robben | |
| 5 | H | LIVERPOOL | 2-0 | Gallas, Crespo | |
| 11 | b | Middlesbrough | 0-3 |
||
| 25 | H | PORTSMOUTH | 2-0 | Lampard, Robben | |
| 4 mars | b | West Bromwich | 2-1 | Drogba, Cole | |
| 11 | H | TOTTENHAM | 2-1 | Essien, Gallas | |
| 19 | b | Fulham | 0-1 |
||
| 25 | H | MANCHESTER CITY | 2-0 | Drogba 2 | |
| 1 apr | b | Birmingham | 0-0 |
||
| 9 | H | WEST HAM | 4-1 | Drogba, Crespo, Terry, Gallas | |
| 15 | b | Bolton | 2-0 | Terry, Lampard | |
| 17 | H | EVERTON | 3-0 | Lampard, Drogba, Essien | |
| 29 | H | MANCHESTER UNITED | 3-0 | Gallas, Cole, Carvalho | |
| 2 maj | b | Blackburn | 0-1 |
||
| 7 | b | Newcastle | 0-1 |
1 |